After 12-months of treatment, the patient no longer met the criteria for OCD (CY-BOCS = 0), although she had residual depressive symptoms (BDI = 10). Discussion The onset of OCD has been linked to reproductive events, with 7% of female patients developing OCD in the postpartum phase (Labad et al, 2005). family. Her current stressors were her pregnancy and subsequent termination of her relationship with her 16 year-old boyfriend. Upon psychiatric review of symptoms, the patient described depressed mood, irritability, guilt and hopelessness. She denied other neurovegetative, manic or psychotic symptoms. Within the last year, she reported one episode of head banging and cutting her wrist in an attempt to relieve her frustration but denied other suicidal acts or homicidal ideation. She felt anxious about her pregnancy but denied specific anxiety symptoms, including obsessions or compulsions. She smoked two joints of marijuana per week but denied other substance use. The patient had no previous psychiatric treatment except for a brief period of counseling for loneliness. Her mother suffers from Bipolar I Disorder and well-controlled OCD. Her previous OCD symptoms consisted of contamination and symmetry obsessions, hand-washing and ordering/arranging compulsions. Her father had a history of alcohol abuse. There was no history of significant medical illness, perinatal complications, developmental delay or ADX-47273 trauma. The patient was given a preliminary diagnosis of adjustment disorder with depressed mood and provided follow-up for further assessment and supportive psychotherapy. The patient had a medical abortion at 9 weeks gestation and was re-assessed 8 weeks after this procedure. Within 1 week of her abortion, she developed progressive hoarding behaviours, involving garbage, water bottles and dirty plates, and was eventually unable to sleep in her bedroom due to the collected items. Furthermore, she endorsed writing copious amounts of lists to track items or events. She believed that if she was unable to remember the significance of or unable to find these items, it would mean she was worthless and would forget everything. Due to her increased hoarding behaviours, the patient stopped attending school and started impairing her familys hygiene. The patient also developed additional depressive symptoms including decreased energy, poor concentration and passive suicidal ideations. Using the Childrens Yale Brown Obsessive-Compulsive scale (CY-BOCS) and Beck Depression Inventory score (BDI), she scored of 23 and 26 on each scale, respectively. Her cannabis use remained unchanged and urine toxicology revealed no other recent substance use. Following this assessment, a trial of fluoxetine was initiated at 10 mg per day in conjunction with cognitive-behavioural therapy (CBT), specifically exposure-response prevention techniques. Due to her persistent symptoms, her fluoxetine dose was gradually titrated to 50 mg/day and risperidone 0. 5 mg at night was added at week 18 to treat residual OCD symptoms and irritability. Her irritability was not uggestive of akathisia or mania. After 22 weeks of CBT and pharmacotherapy treatment, her CY-BOCS and BDI scores decreased to 16 and 14 respectively. She completed a 14 session course of CBT and was maintained on fluoxetine 60 mg and risperidone 0.5 mg per day. After 12-months of treatment, the patient no ADX-47273 longer met the criteria for OCD (CY-BOCS = 0), although she had residual depressive symptoms (BDI = 10). Discussion The onset of OCD has been linked to reproductive events, with 7% of female patients developing OCD in the postpartum phase (Labad et al, 2005). Postpartum OCD is commonly characterized by obsessions of causing harm to the infant (Wisner et AFX1 al, 1999), however, the above case of postpartum CH highlights a rare presentation of OCD in this setting. Although our patient exhibited baseline impulsivity and affective dysregulation, ongoing cannabis use, depressive symptoms and a family history of a mood disorder and OCD, she developed clear symptoms of CH following pregnancy termination. Studies purport that the onset of OCD in the postpartum period may be related to fluctuations in steroid hormones after reproductive events (Labad et al, 2005). Hormonal changes may modify serotonergic transmission and induce hypothalamic-pituitary-adrenal axis dysregulation and are implicated in depression and OCD (Biegon, et al, 1983; Steiner et al, 2003). Although treatment of CH primarily involves selective serotonin reuptake inhibitors (SSRIs), ADX-47273 animal studies suggest that dopamine agonists can produce food hoarding behaviour and that lesions in the dopamine system reduce such symptoms (Blundell, et al, 1977; Kalsbeek et al, 1988). These models support the reported efficacy of SSRI augmentation with dopamine-antagonists, such as risperidone for OCD, however, evidence for the treatment of postpartum OCD without hoarding ADX-47273 is restricted to open-label studies (Bloch et al, 2006; Misri & Milis, 2004). Furthermore, routine antipsychotic augmentation in OCD ADX-47273 is limited by such complications as extrapyramidal symptoms, metabolic disturbances, hyperprolactinemia and paradoxical exacerbation of OCD symptoms. Moderate.