Category: Hydrolases

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* 0.05 versus untreated normal glucose control. 3 protein levels. Results. Our results show that treatment with pioglitazone restored the high glucoseCinduced decrease in IGFBP-3 levels. This regulation was independent of TNF actions, as reducing TNF levels with siRNA did not prevent pioglitazone from increasing IGFBP-3 levels. Pioglitazone required protein kinase A (PKA) and DNA-dependent […]

Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent onset T1DM, it may progress to clinical macrovascular disease

Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent onset T1DM, it may progress to clinical macrovascular disease. with ED in T1DM. The pathogenesis of endothelial dysfunction is closely related to oxidative-stress. NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells, thus reducing nitric […]

Elevated binding of proteins to immunogenic asialo and sialyl core 1, Lewis A, and Lewis Y structures was observed in plasma from patients with sickle cell disease, suggesting a heightened anti-glycan immune response

Elevated binding of proteins to immunogenic asialo and sialyl core 1, Lewis A, and Lewis Y structures was observed in plasma from patients with sickle cell disease, suggesting a heightened anti-glycan immune response. and anti-glycan antibodies in sickle cell disease remain understudied. Here, we compiled results acquired through lectin arrays, glycan arrays, and mass spectrometry […]

LLLT reduced IL-12 secretion from DC stimulated by either LPS or CpG

LLLT reduced IL-12 secretion from DC stimulated by either LPS or CpG. (TLR)-9/nuclear element kappa B (NF-B) activation, were performed. LLLT changed the morphology of LPS-stimulated DC, improved their viability, and modified the balance of DC activation markers (major histocompatibility complex [MHC] class 2 up and CD86 down). LLLT reduced IL-12 secretion from DC stimulated […]